Ultrasound of Epididymitis & Orchitis

In this radiology lecture, we review the ultrasound appearance of acute epididymitis and orchitis!

Key teaching points include:

  • Epididymitis = Inflammation of epididymis. Usually bacterial, most commonly due to retrograde ascent from bladder or prostate.
  • Causative infectious agent varies based on age: Adults younger than 35: Neisseria gonorrhoeae, Chlamydia trachomatis (STDs). Adults older than 35: E. coli & other coliform bacteria.
  • Non-infectious causes of epididymitis: Trauma, repetitive activities such as sports (most common causes in males prior to sexual maturity), torsed appendix testis or appendix epididymis, vasculitis, and medications (amiodarone).
  • Presentation: Gradual onset of scrotal pain, swelling & urinary symptoms. Must exclude testicular torsion (usually more acute onset of pain).
  • Epididymitis US findings: Epididymal enlargement, hyperemia, hypoechogenicity. Hyperemia usually precedes grey scale changes. Infection usually spreads from tail to body and head.
  • 20-30% of epididymitis cases have associated orchitis: Scrotal infection typically starts with epididymis then spreads to testis, scrotal sac, or scrotal wall.
  • Orchitis is less common than and usually secondary to epididymitis. Isolated orchitis uncommon, usually viral (mumps).
  • Orchitis US findings: Testicular enlargement, hyperemia and hypoechogenicity.
  • Complications: Scrotal wall inflammation, complicated hydrocele, pyocele (purulent fluid collection with mass effect), abscess (epididymal, testicular, scrotal wall), testicular ischemia and infarct due to obstructed venous outflow (decreased color Doppler testicular blood flow or reversed testicular diastolic arterial flow).

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Ultrasound of Acute Cholecystitis

In this radiology lecture, we review the ultrasound appearance of acute cholecystitis, including gangrenous and emphysematous cholecystitis!

Key teaching points include:

  • Acute cholecystitis = Acute gallbladder inflammation.
  • Most often (95%) caused by an impacted, obstructing gallstone in the cystic duct or gallbladder neck = Acute calculous cholecystitis.
  • Clinically presents as persistent RUQ pain that may radiate to right shoulder, often with N/V and fever.
  • Ultrasound findings of uncomplicated acute cholecystitis: Gallstones, sonographic Murphy sign, gallbladder wall thickening (greater than 3 mm) and edema, gallbladder distention (greater than 4 cm short axis), and pericholecystic fluid.
  • Sonographic Murphy sign = Maximal abdominal tenderness from transducer pressure over gallbladder. PPV of gallstones and a positive sonographic Murphy sign = 92%.
  • Pericholecystic fluid occurs in less than 20% of patients with acute cholecystitis, usually seen in more advanced cases.
  • Gangrenous cholecystitis = Most common complication of acute cholecystitis. Ischemia with necrosis of gallbladder wall. Increased mortality compared to uncomplicated acute cholecystitis.
  • Ultrasound findings of gangrenous cholecystitis: Wall disruption, ulceration, mucosal irregularity, and/or focal bulge, sloughed mucosal membranes, pericholecystic fluid, less likely to have positive Murphy sign, and increased risk of perforation (usually at fundus).
  • Emphysematous cholecystitis = Gallbladder wall necrosis with gas formation in wall and/or lumen. More common in elderly men with underlying diabetes. Higher risk of perforation, rapid progression, and increased mortality compared to uncomplicated acute cholecystitis. Emergent surgical intervention typically required.
  • Ultrasound findings of emphysematous cholecystitis: Bright reflectors from nondependent portions of gallbladder wall, dirty posterior acoustic shadowing, and ring-down artifact. CT can confirm if necessary.

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Ultrasound of Intussusception

In this radiology lecture, we review the ultrasound appearance of ileocolic and small bowel-small bowel intussusception in children!

Key teaching points include:

  • Intussusception occurs when bowel is pulled into itself or into neighboring bowel.
  • Intussusceptum is the prolapsing bowel pulled into intussuscipiens which receives the bowel.
  • Two major types: Ileocolic and small bowel-small bowel.
  • If ileocolic not reduced = Bowel ischemia and perforation.
  • Most occur in children beyond 3 months of age.
  • Usually no lead point in children (unlike adults), suspected that due to hypertrophic lymphoid tissue after infection.
  • Clinical triad of colicky abdominal pain, vomiting, palpable abdominal mass seen in less than 50% of cases.
  • Red-currant jelly stool = Stool mixed with blood and mucus, can be seen with bowel ischemia.
  • Ultrasound gold standard in diagnosis: Sensitivity and specificity 98%, false negative rate less than 1%.
  • “Target” sign (short axis) and “pseudokidney” sign (long axis) may be seen.
  • Findings suggesting ileocolic (as opposed to small bowel-small bowel) intussusception: Location in right lower quadrant with absent normal ileocolic junction, hyperechoic center indicating mesenteric fat, diameter of hyperechoic core greater than outer wall, lymph nodes inside intussusception, larger AP diameter greater than 2 cm, and longer length greater than 3 cm.
  • Treatment of ileocolic intussusception: Enema with air or contrast material.
  • Findings suspicious for ischemia/necrosis and increased risk of enema reduction failure: Fluid trapped within the intussuscipiens, lack of internal vascular flow on Doppler within the intussusceptum, and irregular bowel wall or decreased bowel wall vascularity.

To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

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Ultrasound of Polycystic Ovarian Syndrome

In this radiology lecture, we review the ultrasound appearance of polycystic ovarian syndrome (PCOS)!

Key teaching points include:

  • PCOS often presents with the clinical triad of oligomenorrhea and/or anovulation, hirsutism, and obesity. Associated with subfertility and recurrent pregnancy loss.
  • Rotterdam criteria (2003) states that PCOS diagnosis requires at least two of the following: Oligo- or anovulation (ovulatory dysfunction), hyperandrogenism (clinical and/or biochemical signs), and polycystic ovarian morphology on ultrasound.
  • Ovaries can be sonographically normal in PCOS. “Hyperandrogenic anovulation” proposed as a more accurate term.
  • Ovaries can also appear polycystic on ultrasound without clinical diagnosis of PCOS.
  • Rotterdam description of polycystic ovaries: 12 or more follicles 2-9 mm in size, and/or ovarian volume greater than 10 cc in at least one ovary (with no dominant cysts).
  • Specific diagnostic cutoffs debated, and 20-25 or more follicles has been more recently suggested as a more accurate cutoff.
  • Supportive morphologic features of PCOS include the “string of pearls sign” (peripheral location of follicles) and prominent, hyperechoic central ovarian stroma.
  • Ovarian morphology typically more important than ovarian size, although a single enlarged, polycystic ovary sufficiently meets ultrasound criteria for PCOS.
  • The term “polycystic” is generally incorrect and “multifollicular” has been offered as a more accurate ultrasound description, but PCOS remains the most widely used term.
  • In post-menopausal women with new or worsening hyperandrogenism, also consider androgen-secreting tumors of ovaries or adrenal glands.

To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

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Ultrasound of Pleomorphic Adenoma of the Parotid Gland

In this radiology lecture, we review the ultrasound appearance of pleomorphic adenoma of the parotid gland!

Key teaching points include:

  • Pleomorphic adenoma AKA benign mixed tumor.
  • Most common salivary gland tumor, most common benign salivary gland tumor, and most common in the parotid gland.
  • Most common in patients aged 40-50, slightly more common in females.
  • For salivary gland masses in adults, the larger the gland, the more likely the tumor is benign: Parotid gland: 80%, submandibular gland: 50%, sublingual glands: 20%.
  • Parotid Gland 80% Rule: 80% of all salivary tumors are in the parotid, 80% of benign parotid gland tumors are pleomorphic adenomas, 80% of pleomorphic adenomas occur in the parotid gland, 80% of pleomorphic adenomas occur in the superficial lobe, and 80% of untreated pleomorphic adenomas stay benign, but 20% can undergo malignant degeneration.
  • On ultrasound, appears as a well-defined mass with lobulated borders, hypoechoic with posterior acoustic enhancement, and with homogeneity of internal echoes common.
  • When large, may have cystic degeneration and internal heterogeneity mimicking malignancy.
  • Vascularity is variable.
  • Describe lesion location, image-guided biopsy planning, evaluate for cervical lymphadenopathy.
  • Superficial and deep parotid lobes divided by facial nerve traveling through gland. Nerve not readily seen, but passes just superficial to adjacent retromandibular vein, which can be seen = Use as a landmark. Inferior to the retromandibular vein, may see branches of the external carotid artery.
  • Treatment is typically excision due to risk of malignant degeneration carcinoma ex pleomorphic adenoma if not completely excised.
  • DDx includes Warthin tumor: Second most common benign parotid tumor, bilateral in 20%, often exhibit cystic components, most common in elderly.
  • Malignant parotid tumors are also in the DDx and may appear with ill-defined margins, irregular shape, heterogeneous internal architecture, extraglandular extension, and adjacent lymphadenopathy.
  • Mucoepidermoid carcinoma: Most common salivary gland malignancy, most common in parotid gland.
  • Adenoid cystic carcinoma: Second most common parotid malignancy, but most common submandibular and minor salivary gland malignancy.
  • Higher risk of perineural spread: Patients may present with facial pain and facial nerve paralysis.

To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

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Ultrasound of Epidermal Inclusion Cyst

In this radiology lecture, we review the ultrasound appearance of epidermal inclusion cyst!

Key teaching points include:

  • Epidermal inclusion cyst is the most common cutaneous cyst.
  • Can occur anywhere: Head, neck, trunk, extremities.
  • Benign, keratin-containing cyst lined by a wall of stratified squamous epithelium.
  • On ultrasound, appears as a well-circumscribed, round to oval mass with broad (50%) contact with dermis, nonvascular and with posterior acoustic enhancement.
  • Hypoechoic to minimally hyperechoic with internal linear echogenic and anechoic debris = “Pseudotestis.”
  • Presence of a focal hypoechoic tract extending towards epidermis adds specificity = “Submarine sign.” May see overlying punctum on skin surface = Small, dark-colored opening.
  • Epidermal inclusion cysts are different from sebaceous cysts. Sebaceous cysts originate from sebaceous glands, contain sebum and are less common.
  • Epidermal inclusion cysts contain keratin, not sebum, but are often incorrectly referred to as sebaceous cysts.
  • Epidermal inclusion cyst vs. epidermoid cyst. Epidermoid cyst is a non-neoplastic cyst lined only by squamous epithelium. Epidermal inclusion cyst is a specific type of epidermoid cyst caused by implantation of epidermal elements in the dermis. All epidermal inclusion cysts are epidermoid cysts, but not all epidermoid cysts are epidermal inclusion cysts.
  • Can become ruptured or infected: Ill-defined or lobular margins, internal blood flow, peri-lesional soft tissue inflammation, adjacent fat focally hyperechoic or hyperemic. DDx for complicated epidermal inclusion cyst: Neurogenic tumors and other neoplasms.
  • Uncomplicated cysts typically do not require treatment, but if infected may require I&D or excision. Growing cysts may also require excision.
  • Rare (1%) malignant degeneration to squamous cell carcinoma, less commonly basal cell carcinoma.

References:
Jacobson JA, Middleton WD, Allison SJ, et al. Ultrasonography of Superficial Soft-Tissue Masses: Society of Radiologists in Ultrasound Consensus Conference Statement. Radiology 2022; 304:18-30. https://pubs.rsna.org/doi/full/10.1148/radiol.211101

To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

Click the YouTube Community tab or follow on social media for bonus teaching material posted throughout the week!

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Ultrasound of Torsion of the Appendix Testis

In this radiology lecture, we review the ultrasound appearance of torsion of the appendix testis and appendix epididymis!

Key teaching points include:

  • Appendix testis is a vestigial appendage usually located between upper pole of testis and head of epididymis.
  • AKA hydatid of Morgagni, the appendix testis is commonly present as a normal finding.
  • Appendix epididymis typically arises from epididymal head.
  • Both scrotal appendages are often pedunculated which increases risk of torsion.
  • Torsion occurs when appendage twists, occluding blood supply.
  • Torsion of the appendix testis is one of most common causes of acute scrotal pain in prepubertal children.
  • Peak age 7-12 years old, but can occur at any age.
  • Normal appendix testis: Oval-shaped, less than 6 mm in size, homogeneously isoechoic to epididymis, and demonstrates little to no blood flow on color Doppler.
  • Torsed appendix testis: 6 mm or larger in size, variable echogenicity, hypoechoic before 24 hours, hyperechoic or heterogeneous after 24 hours.
  • In setting of appendix torsion, hyperemia of surrounding structures with hydrocele and scrotal wall thickening often present.
  • Torsed appendage can detach and become free floating in scrotum.
  • Patients may present with pain localized to upper pole of testis or epididymis.
  • Physical examination may yield the “blue dot” sign: Small, palpable nodule at superior aspect of testis with bluish discoloration of overlying skin due to ischemic appendix.
  • Cremasteric reflex typically intact, and testicle not high riding (unlike testicular torsion).
  • Hyperemia of surrounding structures can be difficult to differentiate from bacterial epididymitis.
  • However, in children, epididymitis usually secondary to inflammation from direct trauma, torsion of a scrotal appendage, or urine reflux into epididymis. Urine dipstick/urinalysis helpful to differentiate from infection.
  • Treatment: Pain management with analgesics, ice, rest. If not recognized, may be treated unnecessarily with antibiotics. Scrotal exploration may be necessary if testicular torsion cannot be excluded.

References:
Baldisserotto M, Ketzer de Souza JC, Pertence AP, Dora MD. Color Doppler sonography of normal and torsed testicular appendages in children. AJR 2005; 184:1287–1292

To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

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Ultrasound of Acute Appendicitis

In this radiology lecture, we review the ultrasound appearance of acute appendicitis with three unique cases!

Key teaching points include:

  • Ultrasound is the first-line imaging modality in pediatric and pregnant patients due to lack of ionizing radiation: Sensitivity/specificity approximately 80%.
  • Technique: Linear transducer with graded compression at site of maximal tenderness using gradual increased pressure to displace normal bowel gas.
  • Inflamed appendix appears as a noncompressible, blind-ending tubular structure arising from cecum.
  • Outer appendiceal diameter with compression: Less than 6 mm almost always normal, 6-8 mm borderline, greater than 8 mm highly suspicious.
  • Thickened appendiceal wall (greater than 2 mm).
  • Wall hyperemia: “Dot flow” normal, continuous linear/curvilinear flow highly suspicious.
  • Increased echogenicity and expansion of peri-appendiceal fat due to infiltration by inflammatory cells and edema.
  • Hyperechoic appendicolith with posterior acoustic shadowing supportive.
  • Identify terminal ileum separate from appendix to differentiate from ileitis, Meckel’s diverticulum, or other small bowel abnormality.
  • Appendix does not exhibit peristalsis.
  • Right lower quadrant free fluid and lymphadenopathy supportive, but nonspecific in isolation.
  • Loss of wall stratification suspicious for necrotic/gangrenous appendicitis, and color Doppler flow may be absent.
  • Gas in appendix appears as dirty shadowing and ring-down artifact. Intraluminal gas sometimes helpful to exclude appendicitis, but can also be seen with gangrenous complication.
  • Peri-appendiceal gas-containing collections highly suspicious for perforation. CT may be needed for clarification.

References:
1) Madhuripan N, Jawahar A, Jeffrey RB, Olcott EW. The Borderline-Size Appendix: Grayscale, Color Doppler, and Spectral Doppler Findings That Improve Specificity for the Sonographic Diagnosis of Acute Appendicitis. Ultrasound Q. 2020;36(4):314-320.
2) Fallon SC, Orth RC, Guillerman RP, et al. Development and validation of an ultrasound scoring system for children with suspected acute appendicitis. Pediatr Radiol. 2015;45(13):1945-1952.

To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

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Ultrasound of Thyroglossal Duct Cyst

In this radiology lecture, we review the ultrasound appearance of thyroglossal duct cyst with two unique cases!

Key teaching points include:

  • Thyroglossal duct cyst is the most common congenital neck cyst.
  • Most present before age 18 as a midline, fluctuant neck mass near hyoid bone.
  • Often asymptomatic unless superinfected = Abscess, draining sinus.
  • Epithelial-lined cysts caused by failure of normal involution of thyroglossal duct.
  • Can occur anywhere from foramen cecum of tongue to thyroid gland.
  • Most are infrahyoid, followed by hyoid and suprahyoid.
  • Most are midline, but can be paramedian (more likely if infrahyoid).
  • If infrahyoid, typically embedded in strap muscles.
  • May move with swallowing and elevates with tongue protrusion.
  • Presence of normal thyroid gland should be confirmed.
  • When simple, typically appears as an anechoic midline neck mass near hyoid bone.
  • Cyst complexity usually due to superinfection: Proteinaceous internal debris and septations, thick irregular walls, increased blood flow and surrounding inflammation.
  • Solid components may indicate ectopic thyroid or rarely (less than 1% of cases) thyroid cancer (typically papillary subtype).
  • Tx: Resection of cyst, surrounding tissue along the thyroglossal tract, and midline portion of hyoid bone = Sistrunk procedure.

To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

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Ultrasound of Varicocele

In this radiology lecture, we review the ultrasound appearance of scrotal varicocele with three unique cases.

Key teaching points include:

  • Varicocele is abnormal dilatation of pampiniform venous plexus = Peritesticular veins.
  • Seen in up to 15% of adult and adolescent males.
  • Caused by incompetent or absent testicular vein valves.
  • Upper limit of normal for scrotal vein caliber = 2 mm, varicocele when greater than 2-3 mm.
  • Flow in varicocele usually too slow to detect with color Doppler and is typically better seen with Valsalva or with standing position.
  • 85% left sided, 15% bilateral: Left testicular vein drains into left renal vein at 90-degree angle, and superior mesenteric artery compresses left renal vein = Increased pressure and venous backflow. Right vein drains into IVC at acute angle.
  • Symptoms: Scrotal mass, pain, infertility/subfertility.
  • Low grade: Reflux only seen with Valsalva, inguinal canal/supratesticular location, vessels enlarged only in standing position.
  • High grade: Reflux seen at rest, infratesticular location, vessels enlarged in supine position.
  • Solitary right varicocele raises concern for compression of the right testicular vein from a retroperitoneal mass.
  • Ultrasound of upper abdomen should be considered when an isolated right-sided varicocele or asymmetrically large right-sided varicocele found.
  • However, most patients typically present with additional signs and symptoms of malignancy: “No patient in our cohort was found to have an unsuspected malignancy for which isolated right-sided varicocele was the only presenting sign.”*

*Gleason A, Bishop K, Xi Y et al. Isolated Right-Sided Varicocele: Is Further Workup Necessary? AJR 2019; 212:802-807

To learn more about the Samsung RS85 Prestige ultrasound system, please visit: https://www.bostonimaging.com/rs85-prestige-ultrasound-system-4

Click the YouTube Community tab or follow on social media for bonus teaching material posted throughout the week!

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